Channel 98005-sk_ch

General data

• ICG id: 2653
• ModelDB id: 98005
• Reference: Maurice N, Mercer J, Chan CS, Hernandez-Lopez S, Held J, Tkatch T, Surmeier DJ (2004): D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons.

Metadata classes

• Animal Model: Sprague-Dawley, mouse, rat, C57BL/6
• Brain Area: basal ganglia, striatum (basal ganglia)
• Neuron Region: soma, dendrites
• Neuron Type: interneuron, cholinergic
• Runtime Q: Q3
• Subtype: SK

Metadata generic

• Age: 3-5 weeks
• Authors: M Migliore, M Lazarewicz
• Comments: Borg-graham type generic k-ahp channel, sk for cholinergic interneuron. From lazarewicz et al. (2002), model no. 20007, with no modifications. Animal model is from experiments in paper. Sk channel kinetics come from previous model of ca3 pyramidal neuron (lazarewicz et al. 2002).
• Runtime: 75.236
• Temperature: No temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp