Channel 20212-kca

General data

• ICG id: 1657
• ModelDB id: 20212
• Reference: Polsky A, Mel BW, Schiller J (2004): Computational subunits in thin dendrites of pyramidal cells.

Metadata classes

• Animal Model: rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, apical trunk
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: slow

Metadata generic

• Authors: A Destexhe
• Comments: Slow ca-dependent potassium current, responsible for slow ahp, activated by intracellular calcium, not voltage dependent. Paper says taken without modification from destexhe et al. (1994). Mod file says modified by y poirazi 2001 (time constant). Paper does not mention model 2488, but the mod files appear to be the same. Taken from mainen & sejnowski (1996), model no. 2488. This is a modeling study, and the animal model is considered to be rat. The authors compare the model to experimental results mostly in rats (e.g. Magee 1998, spruston et al. 1995) and the morphology used is also from rat (2 months old, cannon et al. 1998, n123). Channel kinetics come from various sources.
• Runtime: 71.09
• Temperature: Model has temperature dependence, with q10 set to 3.0 and original kinetics at 22 deg C. Simulations were done at 34 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp