Channel 144490-kca_v2

General data

• ICG id: 1428
• ModelDB id: 144490
• Reference: Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012): Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy.

Metadata classes

• Animal Model: Wistar, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, apical dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q3
• Subtype: not specified

Metadata generic

• Age: P28-42
• Authors: A Destexhe, Y Poirazi
• Comments: Slow ca-dependent potassium current, ca2+ dependent k+ current ic responsible for slow ahp, published in destexhe et al. (1994). Paper lists poirazi et al. (2003) as well as sterratt and van ooyen (2004) as references for the model. Taken from poirazi et al. (2003), model no. 20212, with no changes (identical mod file). [this file is from the folder ca1_multi, directly from poirazi et al. (2003] modeling study, identical to ancestor model save the addition of schaffer collateral spines to dendrites. Experimental results from calcium imaging. Animal model reflects the calcium imaging data. The model was also implemented in two new ca1 pn morphologies but their origin is not clear.
• Runtime: 72.278
• Temperature: Model has temperature dependence, with q10 value set to 3.0 and original kinetics at 22 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp