Channel 143719-cagk

General data

• ICG id: 1250
• ModelDB id: 143719
• Reference: Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012): On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: mAHP

Metadata generic

• Age: P19-24
• Authors: Unknown
• Comments: Calcium-activated k channel, originally from moczydlowski and latorre (1983). This paper’s channels come from poirazi et al. (2003), model no. 20212, and shah et al. (2008), model no. 112546. Both are listed as ancestor channels, although this mod file differs from both in several places, including parameter values for d1, d2, k1, and k2, as well as procedure rate. Experimental and modeling results in this paper. The animal model info here is from the experimental results, morphology was reduced to a single compartment.
• Runtime: 69.788
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp