Channel 101629-h

General data

• ICG id: 8
• ModelDB id: 101629
• Reference: Hemond P, Epstein D, Boley A, Migliore M, Ascoli GA, Jaffe DB (2008): Distinct classes of pyramidal cells exhibit mutually exclusive firing patterns in hippocampal area CA3b.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: CA3, hippocampus
• Neuron Region: soma, dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q4 (slow)
• Subtype: h

Metadata generic

• Age: 4-6 weeks old
• Authors: M Migliore
• Comments: I-h channel from magee 1998 for distal dendrites. Paper cites migliore et al. (1999) and migliore (2003) for kinetics. Migliore (2003), model no 19696, is used because it has all channels. The following modifications exist: vhalfl set to -73 (line 14), new param kl set to -8 (line 15), removal of param zetal, modification of kinetic equations. Experimental results (animal model info here) as well as modeling.
• Runtime: 14.856
• Temperature: Model has temperature dependence. Experiments done at 34 deg C, no mention of simulation temperature.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp