Channel 185355-HCN

General data

• ICG id: 4819
• ModelDB id: 185355
• Reference: Yim MY, Hanuschkin A, Wolfart J (2015): Intrinsic rescaling of granule cells restores pattern separation ability of a dentate gyrus network model during epileptic hyperexcitability.

Metadata classes

• Brain Area: dentate gyrus (DG)
• Neuron Region: distal dendrites
• Neuron Type: granule cell
• Subtype: HCN

Metadata generic

• Authors: Man Yi Yim, Alexander Hanuschkin, Jakob Wolfart
• Comments: Original Mod File: Original name 'hyperde3.mod' Santhakumar V, Aradi I, Soltesz I (2005) J Neurophysiol 93:437-53 https://senselab.med.yale.edu/modeldb/ShowModel.cshtml?model=51781&file=/dentategyrusnet2005/hyperde3.mod Current version by A. Hanuschkin <AH, 2011> for: Yim MY, Hanuschkin A, Wolfart J (2015) Hippocampus 25:297-308. http://onlinelibrary.wiley.com/doi/10.1002/hipo.22373/abstract Mod File history: Chen K, Aradi I, Thon N, Eghbal-Ahmadi M, Baram TZ, Soltesz I: Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nature Medicine, 7(3) pp. 331-337, 2001. (modeling by Ildiko Aradi, iaradi@uci.edu) distal dendritic Ih channel kinetics for both HT and Control animals
• Temperature: celsius = 6.3, q10 = 3^((celsius - 6.3)/10)

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp