1. Channels
  2. IH
  3. 157157-Ih

Channel 157157-Ih

General data

Metadata classes

  • Brain Area: hippocampus
  • Neuron Region: soma, dendrites
  • Neuron Type: pyramidal cell, axo-axonic cell (AAC), basket cell, bistratified cell
  • Subtype: h

Metadata generic

  • Authors: Saudargiene A, Cobb S, Graham BP
  • Comments: Ih current - hyperpolarization-activated nonspecific Na and K channel - contributes to the resting membrane potential - controls the afterhyperpolarization Reference: 1. Maccaferri, G. and McBain, C.J. The hyperpolarization-activated current (Ih) and its contribution to pacemaker activity in rat CA1 hippocampal stratum oriens-alveus interneurons, J. Physiol. 497.1:119-130, 1996. V1/2 = -84.1 mV k = 10.2 reversal potential = -32.9 +/- 1.1 mV at -70 mV, currents were fitted by a single exponetial of t = 2.8+/- 0.76 s at -120 mV, two exponentials were required, t1 = 186.3+/-33.6 ms t2 = 1.04+/-0.16 s 2. Maccaferri, G. et al. Properties of the Hyperpoarization-activated current in rat hippocampal CA1 Pyramidal cells. J. Neurophysiol. Vol. 69 No. 6:2129-2136, 1993. V1/2 = -97.9 mV k = 13.4 reversal potential = -18.3 mV 3. Pape, H.C. Queer current and pacemaker: The hyperpolarization-activated cation current in neurons, Annu. Rev. Physiol. 58:299-327, 1996. single channel conductance is around 1 pS average channel density is below 0.5 um-2 0.5 pS/um2 = 0.00005 mho/cm2 = 0.05 umho/cm2 4. Magee, J.C. Dendritic Hyperpolarization-Activated Currents Modify the Integrative Properties of Hippocampal CA1 Pyramidal Neurons, J. Neurosci., 18(19):7613-7624, 1998 Deals with Ih in CA1 pyramidal cells. Finds that conductance density increases with distance from the soma. soma g = 0.0013846 mho/cm2 dendrite g (300-350 um away) = 0.0125 mho/cm2 see Table 1 in th paper
  • Temperature: p = 5 (degC)

Current Response Traces

Activation
Inactivation
Deactivation
Action Potential
Ramp

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