Channel 170030-h

General data

• ICG id: 3595
• ModelDB id: 170030
• Reference: Miceli F, Soldovieri MV, Ambrosino P, De Maria M, Migliore M, Migliore R, Taglialatela M (2015): Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits.

Metadata classes

• Animal Model: chinese hamster ovary (CHO) cell
• Brain Area: hippocampus, CA1
• Neuron Region: dendrites, distal dendrites
• Neuron Type: pyramidal cell
• Subtype: h

Metadata generic

• Authors: M Migliore
• Comments: From Magee 1998 for distal dendrites
• Temperature: celsius (degC), q10=4.5, qt=q10^((celsius-33)/10). Ephys done at 20-22 deg C, but no mention of simulation temperature.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp