Channel 116983-h

General data

• ICG id: 358
• ModelDB id: 116983
• Reference: Marcelin B, Chauviere L, Becker A, Migliore M, Esclapez M, Bernard C (2009): h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy.

Metadata classes

• Animal Model: rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, axon
• Neuron Type: pyramidal cell
• Runtime Q: Q3
• Subtype: h

Metadata generic

• Age: adult
• Authors: M Migliore
• Comments: I-h channel from magee 1998 for distal dendrites. From migliore et al. (2005), model no. 55035, with the following changes: vhalf changed to -100 (line 14), kl changed to -12 (line 15), replacement of a0t with two parameters a0ta, a0td (lines 17-18), and modification of kinetics (lines 70-71, 79-80). This paper contains experimental results and modeling based on the model in migliore et al. (2005). The animal model info here is from the experimental methods. Furthermore, the morphology used in the model was the same as in migliore et al. (2005), with different aged rats.
• Runtime: 14.515
• Temperature: Model has temperature dependence. Simulations done at 35 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp