Channel 155568-hyperde3

General data

• ICG id: 3346
• ModelDB id: 155568
• Reference: Tejada J, Garcia-Cairasco N, Roque AC (2014): Combined role of seizure-induced dendritic morphology alterations and spine loss in newborn granule cells with mossy fiber sprouting on the hyperexcitability of a computer model of the dentate gyrus.

Metadata classes

• Animal Model: rat
• Brain Area: hippocampus, dentate gyrus (DG)
• Neuron Region: soma, dendrites
• Neuron Type: granule cell, basket cell, hilar mossy cell, hilar perforant-path associated (HIPP) cell
• Runtime Q: Q2
• Subtype: h

Metadata generic

• Authors: I Aradi
• Comments: Ih current from chen et al. (2001). Distal dendritic ih channel kinetics for both ht and control animals. One paper references aradi and holmes (1999, 2002) for kinetics and parameters, while the other references santhakumar et al. (2005). We cite santhakumar et al. (2005), model no. 51781, because all mod files are identical. Modeling study, with identical kinetics to ancestor, santhakumar et al. (2005). Animal model is as specified in paper and ancestors. Age is not clear.
• Runtime: 13.171
• Temperature: Model has temperature dependence, with q10 set to 3 and original kinetics at 6.3 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp