Channel 146026-h
General data
- ICG id: 2834
- ModelDB id: 146026
- Reference: Bahl A, Stemmler MB, Herz AV, Roth A (2012): Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data.
Metadata classes
- Animal Model: rat
- Brain Area: somatosensory cortex, layer 5, cortex
- Neuron Region: dendrites, apical dendrites, dendritic tuft (apical tuft), basal dendrites
- Neuron Type: pyramidal cell
- Runtime Q: Q4 (slow)
- Subtype: h
Metadata generic
- Age: 17-25 days old
- Authors: S Hallermann, A Bahl.
- Comments: Deterministic model of kinetics and voltage-dependence of ih-currents in layer 5 pyramidal neuron. Ancestor channel from kole et al., 2006, model no. 64195. Implemented by stefan hallermann. Added possibility to shift voltage activation (shift) and allowed access to gating variables, armin bahl 2009. Predominantly hcn1 / hcn2. Modeling study that uses experimental data (somatic voltage responses) from bekkers and hausser (2007), which is reflected in the animal model here. Ancestor channel from kole et al. (2008), also of pyramidal neuron in somatosensory cortex.
- Runtime: 15.406
- Temperature: Experiments referenced in paper (Bekkers & Hausser 2007) done at 32-34 deg C. Channel has no temperature dependence, parameters fit to data at 34 deg C.
Current Response Traces
Activation
Inactivation
Deactivation
Action Potential
Ramp
