Channel 98005-hcn12_ch
General data
- ICG id: 2645
- ModelDB id: 98005
- Reference: Maurice N, Mercer J, Chan CS, Hernandez-Lopez S, Held J, Tkatch T, Surmeier DJ (2004): D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons.
Metadata classes
- Animal Model: Sprague-Dawley, mouse, rat, C57BL/6
- Brain Area: basal ganglia, striatum (basal ganglia)
- Neuron Region: soma, dendrites
- Neuron Type: interneuron, cholinergic
- Runtime Q: Q4 (slow)
- Subtype: HCN
Metadata generic
- Age: 3-5 weeks
- Authors: J Held, M Nolan
- Comments: C-amp modulated cation channel. Kinetic model of hcn2 channel gating from wang et al (2002), model no. 19176, with various modifications. J held's adaptation to suit hcn1+2. Animal model is from experiments in paper. Hcn channel kinetics come from previous model of thalamocortical relay cells (wang et al. 2002).
- Runtime: 16.799
- Temperature: Model has temperature dependence.
Current Response Traces
Activation
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Inactivation
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Deactivation
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Action Potential
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Ramp
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