Channel 125152-CAR

General data

• ICG id: 614
• ModelDB id: 125152
• Reference: Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010): Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents.

Metadata classes

• Animal Model: mouse
• Brain Area: hippocampus, CA1
• Neuron Region: unspecified
• Neuron Type: pyramidal cell
• Runtime Q: Q4 (slow)
• Subtype: R-type

Metadata generic

• Age: P40-P60
• Authors: M Horstmann
• Comments: Car channel from royeck et al. (2008), model no. 115356, with no modifications to kinetics. Experimental results and modeling. The animal model here is from the experimental results, the model is the same as the ancestor.
• Runtime: 8.659
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp