1. Channels
  2. Ca
  3. 223649-IL_gutnick

Channel 223649-IL_gutnick

General data

Metadata classes

  • Animal Model: rat
  • Brain Area: hippocampus
  • Neuron Region: unspecified
  • Neuron Type: pyramidal cell
  • Subtype: HVA

Metadata generic

  • Age: 4-6 weeks old
  • Authors: Alturki A, Feng F, Nair A, Guntu V, Nair SS
  • Comments: TITLE High threshold calcium current COMMENT ----------------------------------------------------------------------------- High threshold calcium current ------------------------------ - Ca++ current, L type channels - Differential equations - Model from: Reuveni I; Friedman A; Amitai Y; Gutnick MJ. Stepwise repolarization from Ca2+ plateaus in neocortical pyramidal cells: evidence for nonhomogeneous distribution of HVA Ca2+ channels in dendrites. Journal of Neuroscience, 1993 Nov, 13(11):4609-21. - Experimental data for voltage-dependent activation: Sayer RJ; Schwindt PC; Crill WE. High- and low-threshold calcium currents in neurons acutely isolated from rat sensorimotor cortex. Neuroscience Letters, 1990 Dec 11, 120(2):175-8. - Experimental data for voltage-dependent inactivation: Dichter MA; Zona C. Calcium currents in cultured rat cortical neurons. Brain Research, 1989 Jul 17, 492(1-2):219-29. - Calcium-dependent inactivation was not modeled; if interested, see: Kay AR. Inactivation kinetics of calcium current of acutely dissociated CA1 pyramidal cells of the mature guinea-pig hippocampus. Journal of Physiology, 1991 Jun, 437:27-48. - m2h kinetics from: Kay AR; Wong RK. Calcium current activation kinetics in isolated pyramidal neurones of the Ca1 region of the mature guinea-pig hippocampus. Journal of Physiology, 1987 Nov, 392:603-16. - Reversal potential described by Nernst equation - no temperature dependence included (rates correspond to 36 degC) Alain Destexhe, Laval University, 1996 ----------------------------------------------------------------------------- ENDCOMMENT
  • Temperature: no temperature dependence

Current Response Traces

Activation
Inactivation
Deactivation
Action Potential
Ramp

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