Channel 195615-cal2

General data

• ICG id: 4151
• ModelDB id: 195615
• Reference: Neymotin SA, Suter BA, Dura-Bernal S, Shepherd GM, Migliore M, Lytton WW (2017): Optimizing computer models of corticospinal neurons to replicate in vitro dynamics.

Metadata classes

• Animal Model: mouse
• Brain Area: motor cortex
• Neuron Region: unspecified
• Neuron Type: pyramidal cell
• Subtype: L-type

Metadata generic

• Age: P21 days old
• Authors: Neymotin SA, Suter BA, Dura-Bernal S, Shepherd GM, Migliore M, Lytton WW
• Comments: TITLE L-calcium channel : L-type calcium channel with [Ca]i inactivation : from Jaffe, D. B., Ross, W. N., Lisman, J. E., Laser-Ross, N., Miyakawa, H., and Johnston, D. A. A model for dendritic Ca2 : accumulation in hippocampal pyramidal neurons based on fluorescence imaging measurements. J. Neurophysiol. 71:1O65-1077 1994. : conduction density estimate of 50-200 pS/mu2; 0.0025 S/cm2 (5-20 channels of 10 each) : M. Migliore, E. Cook, D.B. Jaffe, D.A. Turner and D. Johnston, Computer simulations of morphologically reconstructed CA3 : hippocampal neurons, J. Neurophysiol. 73, 1157-1168 (1995). : adapted from http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=3263&file=\ca3_db\cal2.mod : this version from https://senselab.med.yale.edu/ModelDB/ShowModel.asp?model=148094&file=\kv72-R213QW-mutations\cal2.mod : Miceli F, Soldovieri MV, Ambrosino P, Barrese V, Migliore M, Cilio MR, Taglialatela M (2013) Genotype-phenotype : correlations in neonatal epilepsies caused by mutations in the voltage sensor of Kv7.2 potassium channel subunits. PNAS 110:4386-4391
• Temperature: q10 = 5, qt=q10^((celsius-25)/10)

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp