Channel 105385-cal_gp
General data
- ICG id: 37
- ModelDB id: 105385
- Reference: Mercer JN, Chan CS, Tkatch T, Held J, Surmeier DJ (2007): Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons.
Metadata classes
- Animal Model: mouse
- Brain Area: rostral to midlevel, external globus pallidus (GPe), basal ganglia, globus pallidus (GP)
- Neuron Type: globus pallidus (GP) neuron
- Runtime Q: Q4 (slow)
- Subtype: L-type
Metadata generic
- Age: P17-22
- Authors: M Migliore, J Held
- Comments: L-type calcium channel. Adapted from model of ca3 pyramidal neuron in migliore et al. (1995), model no. 3263, with modified parameters and implementation of kinetics. Note that mod files here resemble those of maurice et al. (2004), model no. 98005, but this is not mentioned in paper. animal model is from experiments in paper. Some channel kinetics were fit to data in paper, or constrained by previous studies of rat globus pallidus neurons (baranauskas et al. 1999, 2003) and others (see paper). This channel was adapted from previous model of rodent ca3 pyramidal cell model (migliore et al. 1995).
- Runtime: 8.907
- Temperature: Model has temperature dependence, with q10 set to 3 and original kinetics at 22 deg C. Recordings in paper were done at 22 deg C, and simulations at 23 deg C.
Current Response Traces
Activation
Inactivation
Deactivation
Action Potential
Ramp
