Channel 150024-CaLVA

General data

• ICG id: 3177
• ModelDB id: 150024
• Reference: Ovsepian SV, Steuber V, Le Berre M, O'Hara L, O'Leary VB, Dolly JO (2013): A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.

Metadata classes

• Animal Model: rat
• Brain Area: cerebellum, distal cerebellar nucleus (DCN)
• Neuron Region: soma, dendrites
• Runtime Q: Q2
• Subtype: LVA

Metadata generic

• Age: P75-90
• Authors: J Luthman, V Steuber
• Comments: Low voltage activated calcium current (calva) of deep cerebellar nucleus (dcn) neuron. Uses ghk formulation. The calcium that this channel lets through feeds into the calconc.mod mechanism while calcium entry via the cahva channel is tracked by caconc.mod. Channel kinetics came from previous models in steuber et al. (2011) (genesis) and luthman et al. (2011) (neuron). This mod file was taken from luthman et al. (2011), model no. 144523, with no changes (identical mod file). Animal model comes from experiments in this paper. Morphology used is from rat (p14-17) in steuber et al. (2004), and channel kinetics come from previous studies (luthman et al. 2011, steuber et al. 2011) also on dcn neurons in rat (p13-19)
• Runtime: 7.535
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp