Channel 45539-cat

General data

• ICG id: 2890
• ModelDB id: 45539
• Reference: Traub RD, Contreras D, Whittington MA (2005): Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo.

Metadata classes

• Animal Model: rat
• Brain Area: layer 5, layer 2/3, cortex, auditory cortex, thalamocortical circuit, parietal cortex, layer 6, layer 4, barrel cortex
• Neuron Region: soma, dendrites
• Neuron Type: pyramidal cell, fast rhythmic bursting (FRB), thalamocortical relay cell (TC, TCR), thalamic reticular (RE) cell, regular spiking (RS) cell, intrinsically bursting (IB) cell, fast-spiking (FS) cell, low-threshold spiking (LTS) cell, interneuron, stellate cell, spiny cell, nontufted cell, tufted cell
• Runtime Q: Q1 (fast)
• Subtype: T-type

Metadata generic

• Age: adult
• Authors: M Lazarewicz.
• Comments: Modeling based on traub et al. (1994) and traub et al. (2003c), conductances from traub et al. 2003 and cunningham et al. 2004. This file: calcium low threshold (t-type) current for rd traub 2003, model no. 20756, implemented by m lazarewicz 2003. Minimal changes, inlcluding extra variables to compare with fortran implementation and modification of units. Note: uses nonspecific current, doesn't cause ca2+ influx. Based on data from destexhe et al. (1998). Modeling study, with many neurons in the cortex and thalamus. This channel model is one of two cat channels, with this one mainly being used for glutamatergic cells. The animal model info here is from electrophysiology experiments also in this paper, both in vivo and in vitro.
• Runtime: 7.29
• Temperature: Channel model has no temperature dependence. Experiments done at 34-37 deg C, simulations likely done at physiological temperatures.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp