Channel 98005-cal_ch

General data

• ICG id: 2643
• ModelDB id: 98005
• Reference: Maurice N, Mercer J, Chan CS, Hernandez-Lopez S, Held J, Tkatch T, Surmeier DJ (2004): D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons.

Metadata classes

• Animal Model: Sprague-Dawley, mouse, rat, C57BL/6
• Brain Area: basal ganglia, striatum (basal ganglia)
• Neuron Region: soma, dendrites
• Neuron Type: interneuron, cholinergic
• Runtime Q: Q3
• Subtype: L-type

Metadata generic

• Age: 3-5 weeks
• Authors: M Migliore, M Lazarewicz
• Comments: L-type calcium channel. Migliore file modified by m lazarewicz may 2001. This is the cav1.3 channel. From lazarewicz et al. (2002), model no. 20007, with the following modifications: additional parameters (lines 33-39), and modification of kinetics (lines 105-108). Animal model is from experiments in paper. L-type ca channel kinetics come from previous model of ca3 pyramidal neuron (lazarewicz et al. 2002).
• Runtime: 7.852
• Temperature: Model has temperature dependence, with default at 6.3 deg C. Experiments used to fit model were done at various temperatures.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp