Channel 115356-CAnpq

General data

• ICG id: 256
• ModelDB id: 115356
• Reference: Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008): Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons.

Metadata classes

• Animal Model: mouse
• Brain Area: hippocampus, CA1
• Neuron Region: soma
• Neuron Type: pyramidal cell
• Runtime Q: Q4 (slow)
• Subtype: NPQ

Metadata generic

• Age: 17-21 days
• Authors: M Horstmann.
• Comments: From milgiore mycan2.mod, unknown. No deactivation, activation gate from dimitri, tau midpoint-voltage. Own ghk. T-dependence from mcallister-williams 1995. No apparent modeldb ancestors. Experimental study along with modeling, with morphology from varona et al. (2000). Source of channel kinetics for this model is not clear. The animal model info here is from the experiments in this paper.
• Runtime: 8.873
• Temperature: Model has temperature dependence, with default temperature of 21-22 deg C, and q10 from McAllister-Williams & Kelly (1995).

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp