Channel 53965-IT2

General data

• ICG id: 2141
• ModelDB id: 53965
• Reference: Vitko I, Chen Y, Arias JM, Shen Y, Wu XR, Perez-Reyes E (2005): Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel.

Metadata classes

• Animal Model: human
• Brain Area: thalamocortical circuit
• Neuron Type: thalamocortical relay cell (TC, TCR), thalamic reticular (RE) cell
• Runtime Q: Q3
• Subtype: T-type

Metadata generic

• Age: various
• Authors: A Destexhe, I Vitko
• Comments: Low threshold calcium current responsible for low threshold spikes (lts), model of huguenard & mccormick (1992) for reticular thalamus. Biophysical properties modified from expt data from vitko et al. (2005). Taken from destexhe et al. (1996), model no. 17663, modified to fit new data. Note that the three it2 currents from this model are different from one another. Channels originally from thalamic reticular neurons in cat (destexhe et al. 1996), fit here to new data from human recombinant channels, still aimed at the thalamocortical circuit.
• Runtime: 7.775
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp