Channel 20212-cat

General data

• ICG id: 1634
• ModelDB id: 20212
• Reference: Polsky A, Mel BW, Schiller J (2004): Computational subunits in thin dendrites of pyramidal cells.

Metadata classes

• Animal Model: rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, apical trunk
• Neuron Type: pyramidal cell
• Runtime Q: Q3
• Subtype: T-type

Metadata generic

• Authors: Y Poirazi
• Comments: T-type calcium channel with high threshold for activation, used in somatic and dendritic regions, calculates i_ca using channel permeability instead of conductance. Adapted from magee and johnston (1995), modified to account for ca2+ spikes. No model db ancestors. This is a modeling study, and the animal model is considered to be rat. The authors compare the model to experimental results mostly in rats (e.g. Magee 1998, spruston et al. 1995) and the morphology used is also from rat (2 months old, cannon et al. 1998, n123). Channel kinetics come from various sources.
• Runtime: 7.932
• Temperature: Model has temperature dependence, with q10 set to 3 and original kinetics set to 23.5 deg C. Simulations were done at 34 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp