Channel 144490-car_v2

General data

• ICG id: 1409
• ModelDB id: 144490
• Reference: Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012): Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy.

Metadata classes

• Animal Model: Wistar, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, apical dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: R-type

Metadata generic

• Age: P28-42
• Authors: Y Poirazi
• Comments: Ca r-type channel with medium threshold for activation used in distal dendritic regions, together with calh.mod to help the generation of ca2+ spikes in these regions, written by y poirazi 2000. Taken from poirazi et al. (2003), model no. 20212, with no changes (identical mod file). [this file is from the folder ca1_multi, directly from poirazi et al. (2003] modeling study, identical to ancestor model save the addition of schaffer collateral spines to dendrites. Experimental results from calcium imaging. Animal model reflects the calcium imaging data. The model was also implemented in two new ca1 pn morphologies but their origin is not clear.
• Runtime: 7.367
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp