Channel 144490-calH_v2

General data

• ICG id: 1405
• ModelDB id: 144490
• Reference: Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012): Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy.

Metadata classes

• Animal Model: Wistar, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, apical dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: L-type

Metadata generic

• Age: P28-42
• Authors: Y Poirazi
• Comments: Ca l-type channel with high threshold of activation inserted in distal dendrites to account for distally restricted initiation of ca2+ spikes, written by y poirazi 2000. Taken from poirazi et al. (2003), model no. 20212, with no changes (identical mod file). [this file is from the folder ca1_multi, directly from poirazi et al. (2003] modeling study, identical to ancestor model save the addition of schaffer collateral spines to dendrites. Experimental results from calcium imaging. Animal model reflects the calcium imaging data. The model was also implemented in two new ca1 pn morphologies but their origin is not clear.
• Runtime: 7.467
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp