Channel 112834-caL

General data

• ICG id: 140
• ModelDB id: 112834
• Reference: Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O'Donnell P, Finkel LH (2005): NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron.

Metadata classes

• Animal Model: rat
• Brain Area: basal ganglia, nucleus accumbens (NAcc)
• Neuron Region: soma, dendrites
• Neuron Type: medium spiny projection (MSP) neuron
• Runtime Q: Q3
• Subtype: L-type

Metadata generic

• Age: 48-59 days
• Authors: J Moyer.
• Comments: Inactivating hva l-type (1.2) calcium channel for nucleus accumbens neuron, using ghk equation. Written by j moyer 2004. Lists the following citations: brown et al. (1993), churchill & macvicar (1998) for activation steady-state params, kasai & neher (1992) for kinetics, mermelstein et al. (1999), randall & tsien (1995), koch & segev (1998), and hill (1992). Inactivation was taken from the cav1.3 model. No apparent modeldb ancestors. Animal model is from experiments in paper. Channel data comes mostly from churchill & macvicar 1998, on adult rat accumbal cells, kinetics originally from kasai & neher 1992, bell et al (2001).
• Runtime: 8.072
• Temperature: Model has temperature dependence. Experiments done at 33-35 deg C, simulations at 35 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp