Channel 143719-somacar

General data

• ICG id: 1267
• ModelDB id: 143719
• Reference: Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012): On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: R-type

Metadata generic

• Age: P19-24
• Authors: Y Poirazi
• Comments: Ca r-type channel with medium threshold for activation used in somatic regions, lower threshold for activ/inactiv and slower activation time constant than the same mechanism in dendritic regions, written by y poirazi 2001. From poirazi et al. (2003), model no. 20212, with modification. Experimental and modeling results in this paper. The animal model info here is from the experimental results, morphology was reduced to a single compartment.
• Runtime: 7.408
• Temperature: Model has temperature dependence, with default temperature of 34 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp