Channel 143719-car

General data

• ICG id: 1253
• ModelDB id: 143719
• Reference: Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012): On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, apical dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q1 (fast)
• Subtype: R-type

Metadata generic

• Age: P19-24
• Authors: Y Poirazi, M Markaki
• Comments: Ca r-type channel with medium threshold for activation, used in distal dendritic regions, together with calh.mod, to help with the generation of ca2+ spikes in these regions, written by y poirazi 2000, updated by c gold 2003, m markaki 2003. From poirazi et al. (2003), model no. 20212, with modification. Experimental and modeling results in this paper. The animal model info here is from the experimental results, morphology was reduced to a single compartment.
• Runtime: 7.183
• Temperature: Model has temperature dependence

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp