Channel 143719-calH

General data

• ICG id: 1252
• ModelDB id: 143719
• Reference: Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012): On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: hippocampus, CA1
• Neuron Region: dendrites, distal dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q1 (fast)
• Subtype: L-type

Metadata generic

• Age: P19-24
• Authors: Y Poirazi
• Comments: Ca l-type channel with high threshold of activation, inserted in distal dendrites to account for distally restricted initiation of ca2+ spikes, written by y poirazi 2000. From poirazi et al. (2003), model no. 20212, with several modifications including removal of procedures calcg and mhn. Experimental and modeling results in this paper. The animal model info here is from the experimental results, morphology was reduced to a single compartment.
• Runtime: 7.306
• Temperature: Model has no apparent temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp