Channel 143719-cal

General data

• ICG id: 1251
• ModelDB id: 143719
• Reference: Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012): On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, apical dendrites, apical trunk
• Neuron Type: pyramidal cell
• Runtime Q: Q3
• Subtype: L-type

Metadata generic

• Age: P19-24
• Authors: Unknown
• Comments: L-type calcium channel. This paper’s channels come from poirazi et al. (2003), model no. 20212, and shah et al. (2008), model no. 112546. Both are listed as ancestor channels, although this mod file differs from both in several places, including parameters and procedures. Model is more similar to the one in poirazi et al. Experimental and modeling results in this paper. The animal model info here is from the experimental results, morphology was reduced to a single compartment.
• Runtime: 7.751
• Temperature: Model has temperature dependence with default temperature of 34 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp