Channel 168858-naz_nature

General data

• ICG id: 3930
• ModelDB id: 168858
• Reference: Coskren PJ, Luebke JI, Kabaso D, Wearne SL, Yadav A, Rumbell T, Hof PR, Weaver CM (2015): Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex.

Metadata classes

• Animal Model: rhesus monkey
• Brain Area: layer 2/3, cortex
• Neuron Region: unspecified
• Neuron Type: pyramidal cell
• Subtype: not specified

Metadata generic

• Age: 4 young (8.0±2.8 years old) and 2 aged (22.4±3.4 years old)
• Authors: Z Mainen
• Comments: Sodium channel with Hodgkin-Huxley style kinetics. Kinetics were fit to data from Huguenard et al. (1988) and Hamill et al. (1991). Credited author is Zach Mainen (1994). Qi is not well constrained by the data, sinc there are no points between -80 and -55. So this was fixed at 5 while the thi1, thi2, Rg, and Rd were optimized using a simplex least square proc. Voltage dependencies are shifted approximately from the best fir to give higher threshold.
• Temperature: Model has temperature dependence. Original temperature of 23 degC, q10 = 2.3

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp