Channel 45539-naf_tcr

General data

• ICG id: 2907
• ModelDB id: 45539
• Reference: Traub RD, Contreras D, Whittington MA (2005): Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo.

Metadata classes

• Animal Model: rat
• Brain Area: layer 5, layer 2/3, cortex, auditory cortex, thalamocortical circuit, parietal cortex, layer 6, layer 4, barrel cortex
• Neuron Region: soma, dendrites, axon
• Neuron Type: pyramidal cell, fast rhythmic bursting (FRB), thalamocortical relay cell (TC, TCR), thalamic reticular (RE) cell, regular spiking (RS) cell, intrinsically bursting (IB) cell, fast-spiking (FS) cell, low-threshold spiking (LTS) cell, interneuron, stellate cell, spiny cell, nontufted cell, tufted cell
• Runtime Q: Q1 (fast)
• Subtype: fast

Metadata generic

• Age: adult
• Authors: T Morse, M Lazarewicz.
• Comments: Modeling based on traub et al. (1994) and traub et al. (2003c), conductances from traub et al. 2003, model no. 20756, and cunningham et al. 2004. Fast na kinetics based on quantitative data in martina and jonas (1997). Specifically for tcr cells. Implemented by m lazarewicz, 2003, modified by t morse 2006 --fastnashift init to 0 and removed from arg modifications. Further changed to match naf in tcr, with additional shift parameters. Modeling study, with many neurons in the cortex and thalamus. This channel model is primarily for tcr cells. The animal model info here is from electrophysiology experiments also in this paper, both in vivo and in vitro.
• Runtime: 4.34
• Temperature: Channel model has no temperature dependence. Experiments done at 34-37 deg C, simulations likely done at physiological temperatures.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp