Channel 53965-HH2

In other classes K

General data

• ICG id: 2140
• ModelDB id: 53965
• Reference: Vitko I, Chen Y, Arias JM, Shen Y, Wu XR, Perez-Reyes E (2005): Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel.

Metadata classes

• Animal Model: human
• Brain Area: thalamocortical circuit
• Neuron Type: thalamocortical relay cell (TC, TCR), thalamic reticular (RE) cell
• Runtime Q: Q4 (slow)
• Subtype: HH

Metadata generic

• Age: various
• Authors: A Destexhe
• Comments: Hippocampal hh channels: fast na+ and k+ currents responsible for action potentials. Equations modified from traub & miles (1991), written by a destexhe aug 1992. Taken from destexhe et al. (1996), model no. 17663. Channels originally from thalamic reticular neurons in cat (destexhe et al. 1996), fit here to new data from human recombinant channels, still aimed at the thalamocortical circuit.
• Runtime: 5.257
• Temperature: Model has temperature dependence, with original kinetics at 36 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp