Channel 139653-Nap_Et2

General data

• ICG id: 1093
• ModelDB id: 139653
• Reference: Hay E, Hill S, Schurmann F, Markram H, Segev I (2011): Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties.

Metadata classes

• Animal Model: Wistar, rat
• Brain Area: layer 5, cortex
• Neuron Region: soma
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: persistent

Metadata generic

• Age: P36
• Authors: E Hay
• Comments: Modeled according to kinetics derived from magistretti & alonso (1999), mtau deduced from text, equations used from nat and modified. No apparent modeldb ancestors, although there are several other persistent sodium channel models that base some or all of their kinetics from magistretti & alonso (1999). Modeling study, that is constrained by experimental data (animal model here) (see le be et al. 2007). Channel kinetics come from various sources.
• Runtime: 4.562
• Temperature: Model has temperature dependence. Original temperature is 21 deg C. Here, qt is set to 2.3, to adjust kinetics for simulations at 34 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp