Channel 118986-kdrca1

General data

• ICG id: 384
• ModelDB id: 118986
• Reference: Miceli F, Soldovieri MV, Lugli L, Bellini G, Ambrosino P, Migliore M, del Giudice EM, Ferrari F, Pascotto A, Taglialatela M (2009): Neutralization of a unique, negatively-charged residue in the voltage sensor of K V 7.2 subunits in a sporadic case of benign familial neonatal seizures.

Metadata classes

• Animal Model: rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: delayed rectifier (dr)

Metadata generic

• Age: 5-6 weeks old
• Authors: M Migliore
• Comments: K-dr channel from shah et al. (2008), model no. 112546, without modification (identical mod file). Results from clinical experiments for kv7 channel, then combined into the ca1 model from the ancestor. The results are not used here for kdr, so the animal model info is from the ancestor model.
• Runtime: 7.431
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp