Channel 114394-Kv1

General data

• ICG id: 231
• ModelDB id: 114394
• Reference: Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008): Action potential generation requires a high sodium channel density in the axon initial segment.

Metadata classes

• Animal Model: Wistar, rat
• Brain Area: somatosensory cortex, layer 5, cortex
• Neuron Region: soma, dendrites, axon, axon hillock, axon initial segment (AIS)
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: 1

Metadata generic

• Age: 2-4 weeks old
• Authors: W Akemann
• Comments: Voltage-gated low threshold potassium current from kv1 subunits. Kinetic data taken from zerr et al. (1998), from akemann and knoepfel (2006), model no. 80769, with modified constants (lines 53-59), but same kinetics. This paper contains experimental results from rats, as well as modeling based on a previous model. The animal model info here is from the experimental results, the morphology of the model is not specified, could also come from the ancestor model. These channel kinetics were previously used in cerebellar purkinje cell model (akemann & knoepfel 2006)
• Runtime: 7.646
• Temperature: Model has temperature dependence, with original kinetics at 22 deg C. Simulations run here at 37 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp