Channel 20212-kaprox

General data

• ICG id: 1655
• ModelDB id: 20212
• Reference: Polsky A, Mel BW, Schiller J (2004): Computational subunits in thin dendrites of pyramidal cells.

Metadata classes

• Animal Model: rat
• Brain Area: hippocampus, CA1
• Neuron Region: dendrites, proximal dendrites, apical trunk, basal dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q4 (slow)
• Subtype: A

Metadata generic

• Authors: M Migliore
• Comments: K-a channel from migliore et al. (1999), model no. 2796 (from klee, ficker and heinemann (1995) as well as hoffman et al (1997)), modified by t brannon and y poirazi to account for hoffman et al (1997) proximal region kinetics. It is not clear if kinetics have been altered from the ancestor model. Used only in locations <100 microns from the soma and in the soma. This is a modeling study, and the animal model is considered to be rat. The authors compare the model to experimental results mostly in rats (e.g. Magee 1998, spruston et al. 1995) and the morphology used is also from rat (2 months old, cannon et al. 1998, n123). Channel kinetics come from various sources.
• Runtime: 8.176
• Temperature: Model has temperature dependence, with q10 set to 5.0 and original kinetics at 24 deg C. Simulations were done at 34 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp